About the position

Laboratory engineer for research project on developing and testing patient derived micro-physiological liver 3D models in the frame of the Wellcome Leap “dynamic resilience” program.

A two-year Laboratory engineer (SKO 1085) is available at the Hybrid Technology Hub – Centre of Excellence (HTH-CoE;) Institute of Basic Medical Sciences, University of Oslo, Norway in collaboration with the Department of Transplantation Medicine at the Oslo University Hospital. The recruited candidate will work with an interdisciplinary team on developing and testing female patient-derived liver spheroids with the aim of identifying age and patient specific response differences to stressors.

Job description

The work will include setting up qualitative and functional assays, including single-cell RNA sequencing (scRNAseq)." Subsequently, the liver spheroid platform will undergo stressor exposure, and any donor-specific alterations will be documented. The engineer will enter a well-established interdisciplinary team that includes an organ-on-chip platform designer, an expert on liver organoids, a technician working on patient derived liver spheroids, transplant physicians, surgeons and sequencing/sequence analysis experts.

It is important that the candidate is comfortable with a highly dynamic work environment that must deliver milestones within the agreed timeframe. It is essential that the candidate can cope with flexible working hours as human material from the clinical transplant activity - which the liver spheroids are established from - may arrive on evenings or weekends. In return we offer an exciting opportunity to work at the forefront in science in a world-leading, international research environment see https://doi.org/10.1016/j.crmeth.2023.100440  with the opportunity to travel to the project collaborators at the University of Tubingen, Germany and at the Welcome Sanger Institute UK.

Qualification requirements

• A Master degree or equivalent in cell biology, molecular biology or related subjects. The applicant is required to document that the degree corresponds to the profile for the position. The master dissertation must be submitted for evaluation by the application deadline. The appointment is dependent on the master thesis being approved.
• Substantial cell culture experience including handling of human primary cells.
• Good knowledge of, and experience with, molecular biology methods and imaging techniques.
• Expertise in 3D cell models is an advantage.
• Expertise in micro-physiological systems is an advantage.
• Expertise in advanced -omics such as RNA seq data analysis is an advantage.
• Fluent oral and written communication skills in English.
• Personal suitability and motivation for the position.

Desired skills:

The master dissertation must be submitted for evaluation by the application deadline. The appointment is dependent on the master thesis being approved.

• Expertise in 3D cell models is an advantage.
• Expertise in micro-physiological systems is an advantage.
• Expertise in advanced -omics such as RNA seq data analysis is an advantage.

In the evaluation of the applications, emphasis will be placed on:

• The applicant’s academic qualifications.
• The applicant’s estimated academic and personal ability to carry out the project within the contractual time frame.
• Demonstrated ability to design and execute experiments and interpret, report, and troubleshoot complex data.
• The applicant’s skills to work in a team within and across disciplines and personal suitability for the position.

We offer

• Salary NOK 516 800 – 575 400 per annum depending on qualifications in position as laboratory engineer (position code 1085)
• The applicant’s academic qualifications.
• The applicant’s estimated academic and personal ability to carry out the project within the contractual time frame.
• Demonstrated ability to design and execute experiments and interpret, report, and troubleshoot complex data.
• The applicant’s skills to work in a team within and across disciplines.

How to apply

The application must include:

• Cover letter statement of motivation and research interests.
• CV (summarizing education, positions, and academic work).
• Copies of educational certificates (academic transcripts only).
• A complete list of publications and academic works.
• List of at least two reference persons (name, relation to candidate, e-mail and phone number).
• Letters of recommendation (optional).

The application with attachments must be delivered in our electronic recruiting system, please follow the link “Apply for this job”. Foreign applicants are advised to attach an explanation of their Universitys grading system. Please note that all documents should be in English (or a Scandinavian language). When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project. Applicants may be called in for an interview.

Formal regulations

Interviews with the best qualified candidates will be arranged.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition.

Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

Contact information

• Centre director Prof. Stefan Krauss, Stefan.krauss@medisin.uio.no
• Centre PI Prof. Espen Melum, espen.melum@medisin.uio.no
• Dr. Aleksandra Aizenshtadt, aleksandra.aizenshtadt@medisin.uio.no
• Administrative coordinator Dr. Petter A Olsen peteraol@medisin.uio.no

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