Ledig stilling på Universitetet i Oslo
PhD Fellowship on Nuclear Envelope Dynamics in Cancer Cells
Universitetet i Oslo
The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.
The Institute of Basic Medical Sciences overall objective is to promote basic medical knowledge in order to understand normal processes, provide insight into mechanisms that cause illness, and promote good health. The Institute is responsible for teaching in basic medical sciences for the programmes of professional study in medicine and the Master's programme in clinical nutrition. The Institute has more than 300 employees and is located in Domus Medica.
A 3-year PhD student position (SKO 1017) is available at the Department of Molecular Medicine, Institute for Basic Medical Sciences, University of Oslo. The position is related to the project “Nuclear Integrity – from Molecular Mechanism to Cell Fate” funded by the Norwegian Research Council.
More about the position
The Campsteijn lab seeks a highly motivated PhD student candidate to study the molecular mechanisms ensuring nuclear integrity and their role in cell fitness and fate.
Major breakthroughs over the last years have highlighted the importance of nuclear envelope integrity. Despite being the subject of intense studies in a rapidly expanding field, the processes at sites of nuclear envelope ruptures and their long-term consequences on cell fate remain poorly understood.
The central aim of this project is to identify and characterize processes associated with transient lapses in nuclear integrity.
The candidate will
- characterize novel regulators of nuclear integrity at mechanistic, spatiotemporal and ultrastructural levels.
- establish genetics and mechanobiology approaches for controlled induction of nuclear ruptures.
- develop novel technologies to monitor and track cells experiencing lapses in nuclear integrity.
- determine short- and long-term effects of nuclear ruptures on nuclear architecture and genome stability, on inflammation, senescence, and cell fitness, and ultimately on cell fate.
To address these questions, the candidate will use a range of advanced molecular cell biology approaches including live-cell and ultrastructural microscopy, genetics and proteomics.
The Campsteijn lab focuses on nuclear envelope dynamics in healthy cells, under pathological conditions and upon biomechanical stress. We draw on extensive experience using mechanistic cell biology to study nuclear dynamics and integrity, genome stability and biology, in a range of (cancer) cell models. Local research infrastructure includes a well-equipped laboratory and access to advanced (live-cell) microscopy, genetics and proteomics facilities, amongst others.
The research fellow must take part in the Faculty’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.
For more information, please see our web site .
- Applicants must hold a Master’s degree (120 ECTS) in molecular cell biology, biochemistry or equivalent. The Master’s degree must include a thesis of at least 30 ECTS
- A strong drive for fundamental mechanistic research
- Motivation for the position and commitment to carry out high-level research
- Eagerness to integrate and work in a versatile and cross-disciplinary team
- The ability to take scientific initiatives and troubleshoot complex challenges
- Excellent communication skills, including proficiency in spoken and written English
- Experience with relevant research topics and techniques will be a major advantage
- A challenging, stimulating and attractive working environment
- Participation in ambitious mechanistic cell biology projects involving a wide range of experimental approaches
- Salary NOK 491 200 - 534 400 per annum depending on qualifications as PhD research fellow, (position code 1017)
- Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities
- Opportunities and support for career development
How to apply
The application must include
- Application letter including statement of motivation for this PhD position
- CV summarizing education, positions and relevant work experience including research
- Complete list of publications
- Copies of educational certificates
- List of 2-3 references stating relation to the candidate, with contact information
- Application material should be in English
The application with attachments must be delivered in our electronic recruiting system, please follow the link “Apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project. Interviews with the best qualified candidates will be arranged.
Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.
No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.
According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.
Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. We also want to have employees with diverse expertise, combinations of subjects, life experience and perspectives. We will make adjustments for employees who require this.
If there are qualified applicants with special needs, gaps in their CVs or immigrant backgrounds, we will invite at least one applicant in each of these groups to an interview.
- Coen Campsteijn, email: [email protected]