Postdoctoral Fellow in Computational Biology & Gene Regulation

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership for Molecular Medicine

The Computational Biology & Gene Regulation group led by Anthony Mathelier at the NCMM, a part of the Nordic EMBL Partnership for Molecular Medicine, is seeking an ambitious and highly motivated Postdoctoral Fellow for a two-year position (with possibility of extension) funded through the TFmeCan project funded by the Norwegian Cancer Society, starting in October 2024.

Position Description

The selected candidate will contribute to the TFmeCan project funded by the Norwegian Cancer Society to further characterize the interplay between TF-DNA interactions and DNA methylation patterns in breast cancer cells.

Key responsibilities

• Update our JASPAR and UniBind databases.
• Study the interplay between TF binding and DNA methylation through cell type deconvolution and expression-methylation quantitative trait loci analyses.

Requirements

The ideal candidate should meet the following criteria:

• Ph.D. in Computational Biology, Bioinformatics, or a related field defended in the last 3 years or close to completion at the time of submission.
• Demonstrated ability to work with high-throughput sequencing data.
• Experience with TF-DNA interaction models and genomic interpretation tools.
• Knowledge of transcriptional regulation.
• Experience with the integration and analysis of multi-omics datasets.
• Documented experience with leading the development of open-source and self-contained computational software.
• Track record of developing reproducible computational pipelines, preferably with workflow management systems like Snakemake.
• Ability to containerize applications using Docker or Singularity for better software management and reproducibility.
• At least one first author publication in an international peer-reviewed journal within the last 2 years.
• Ability to collaborate with researchers from different fields and at different career stages.
• Willingness to be part of a team to share knowledge and skills.
• Documented ability to communicate science.
• Excellent written and verbal communication skills in English.
• Prior experience with the JASPAR or UniBind databases will be a selective advantage.

What we offer

• A salary of NOK 575 400 - 657 300 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)
• A stimulating research project that will have an impact on the scientific community.
• A role within an ambitious and multi-disciplinary team that combines the strengths of both experimental and computational sciences, aimed at delivering high-impact research.
• Attractive welfare benefits including a generous pension agreement.
• A family-friendly environment in Oslo, known for its high quality of life, rich cultural scene, and abundant opportunities for outdoor activities.

Application Procedure

Applicants should include (1) a cover letter outlining motivations, career goals, relevant experience, and research interests, (2) a CV with list of publications, and (3) two-three referees contact information. These should be uploaded as a single PDF document in the electronic recruiting system. All documents should be in English.

Interviews with the best qualified candidates will be arranged.

It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Formal regulations

Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.

No one can be appointed for more than one Postdoctoral Fellow period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

Contact information

Inquiries about the position can be directed to Anthony Mathelier

About the application: Nina Modahl

Apply for position