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Researcher – gene editing and cell-based therapy

Deadline: 15.06.2023

Universitetet i Oslo

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 800 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.

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Job description

Applicants are invited for a three-year position as a researcher on gene correction in inherited bleeding disorders in the Hematology group at the Research Institute for Internal Medicine and Dept. of Hematology, Oslo University Hospital (Rikshospitalet), and Institute of Clinical Medicine, University of Oslo.

The research group has conducted basic, translational and clinical research within hematology for more than 30 years, with focus on blood coagulation and hemostasis. The group currently counts 10 members and is diverse in related to experience, competence/background, and nationality. We are organized under the R&D section at the department of Hematology and since 2012 we have been part of the Research Institute of Internal Medicine.

More about the position

In the project you will work on a genetic bleeding disorder called inherited factor (F) VII deficiency. Using advanced cell reprogramming techniques and CRISPR gene editing, we correct the disease-causing mutation to restore FVII activity and function in cells.

You will have a central role in this project, ensuring experimental progress and coordination of the work packages and team members, and you will be part of the project management group together with the group leader and PI. The position is 100% over a three-years period but is open for flexibility and/or extensions.

Qualification requirements

  • PhD (or a degree equivalent to a Norwegian doctoral degree) in medicine or molecular biology + minimum of 5 years relevant research experience
  • The candidate must document practical experience and in-depth understanding of CRISPR/Cas9 gene editing, reprogramming of somatic cells to stem cells, and differentiation of stem cells into lineage defined cells/organoids (preferably hepatic)
  • Experienced in data handling and interpretations, data presentation and publication
  • Experience with project management, supervision, grant writing, and collaboration
  • Fluent oral and written communication skills in English

Personal skills

  • Ability to work independently, with good analytical and problem-solving skills
  • Well organized and structured, with high working capacity and productivity
  • Good social competence including skills in team work, communication, and collaborative initiative
  • Flexible

We offer

  • Salary NOK 679 700 – NOK 732 300 per annum depending on qualifications in position as Researcher (position code 1109)
  • A professionally stimulating working environment
  • Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

How to apply

The application must include:

  • Cover letter (statement of motivation, summarizing scientific work and research interest).
  • CV (summarizing education, positions, supervision experience, administrative experience and other qualifying activities).
  • Copies of educational certificates (academic transcripts only).
  • A complete list of publications.
  • Any research publications that the applicant wishes to be considered.
  • List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number).

The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).

In assessing the applications, special emphasis will be placed on the documented, academic qualifications, the project description and the quality of the project as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.

Formal regulations

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

Contact information

  • Principal Investigator, professor Per Morten Sandset, email: p.m.sandset@medisin.uio.no
  • Group leader/Senior Researcher, Benedicte Stavik, email: benedicte.stavik@ous-research.no
  • Senior HR Adviser Thoril Kristiansen, email: thoril.kristiansen@medisin.uio.no

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