Job description

A researcher position is available for 1 year from March 2020, at the KG Jebsen Centre for B-cell malignancies. The position will be affiliated with the Lymphoma Biology Group at the Institute for Cancer Research, headed by June H. Myklebust.

The organization and research focus

The KG Jebsen Centre includes 3 research labs and 2 clinical groups at Oslo University Hospital, located at Rikshospitalet and Radiumhospitalet, and currently counts more than 50 members. The centre aims to improve the biological understanding of B-cell malignancies, and will translate these advances into improved patient treatment. B-cell malignancies are cancers derived from B-lymphocytes of the immune system and constitute a heterogeneous group of malignancies. A precise diagnosis is crucial, as the different disease types require different treatment regimens for optimal control. The centre is a multidisciplinary integration of life science research including drug discovery, design and innovation, molecular biology and molecular medicine/personalized medicine, biostatistics/informatics, ground breaking cell-based immunotherapy, as well as clinical trials and establishment of best practice on how to treat B-cell malignancies. The position will be affiliated with the Lymphoma Biology Group, which focuses on translational studies in B-cell lymphoma. The research milieu consists of immunology researchers with research background in medicine, biology, biochemistry and biotechnology, experts in computational biology and biostatistics, oncologists with translational research experience and hematopathologists, and we have extensive international collaboration. See http://www.med.uio.no/klinmed/english/research/centres/kgj-b-cell-malignancies/

More about the position

The position is integrated in the KG Jebsen centre research focus to identify molecular predictive signatures for B-cell malignancies and to gain new biological insight in tumor cell heterogeneity and the interplay with the microenvironment.

The centre uses primary patient samples from patients included in clinical trials. The hired researcher will be involved in ongoing studies to characterize tumor infiltrating T cells in lymphoma tumors with respect to immune checkpoint receptor expression and degree of functionality. The researcher will also be involved in lymphoma precision medicine study, with establishment of lymphoma derived xenograft models. The hired researcher will use advanced fluorescent flow cytometry and mass cytometry, various cell biology and immunological assays, and will be involved in establishing lymphoma patient derived xenograft mouse models The project is conducted in close collaboration with other postdocs in the lab, lymphoma clinicians and members of the KG Jebsen centre.

Qualification requirements and personal skills

• Applicants must hold a PhD in cancer biology/ immunology.
• Documented strong background in tumor immunology in lymphoma and candidates with strong expertise in immune checkpoint receptor biology and T-cell signaling will be preferred.
• Experience from work with single cell proteomics technologies such as advanced flow cytometry and mass cytometry as well as experience with in vivo experiments is required.
• Animal certification (FELASA C) is mandatory.
• Proficient in written and oral English.
• The candidate should be highly motivated and dedicated. Good team working skills are required.

We offer

• A dynamic and stimulating scientific environment in a young, enthusiastic and motivated team of biologists and MDs. The Institute of Cancer Research is at the international forefront and houses top modern (2009) and excellent lab facilities with a wide range of core facilities (animal, light and electron microscopy, flow cytometry, genomics and bioinformatics, MR), with additional core facilities (mass spec etc) at the Rikshospitalet and UiO sites.
• Salary NOK 523 200 - NOK 615 900 per annum depending on qualifications (position code 1109).
• Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities.

How to apply

The application must include

• Cover letter (statement of motivation, summarizing scientific work and research interest)
• CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
• A complete list of publications
• Transcripts of university diplomas
• List of 3 referee persons (name, relation to candidate, e-mail and phone number)

The application with attachments must be delivered in our electronic recruiting system, please follow the link “Apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language). In assessing the applications, special emphasis will be placed on the documented, academic qualifications, as well as the candidates motivation and personal suitability.

Formal regulations

According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.

Contact information

• Associate Professor June H. Myklebust, june.myklebust@medisin.uio.no or to
  
• Professor Erlend B. Smeland, ebs@ous-hf.no

Information about the electronic application form can be addressed to Senior HR Adviser Thoril Kristiansen, thoril.kristiansen@medisin.uio.no

Apply for this job