Stilling:
PhD Fellowship in breast cancer research
Deadline 03.08.2018
Job description
A Ph.D. Research Fellow position is available at the Institute of Basic Medical Sciences in the Department of Nutrition in the group led by Professor Jason Matthews. This project will study the basic and translational aspects of the post-translational modification, mono-ADP-ribosylation, in breast carcinogenesis.
The fellowship will be for a period of 3 years, with the possibility of a fourth year with 25% compulsory work (e.g. teaching responsibilities at the department), which will be contingent on the qualifications of the candidate and the teaching needs of the department.
Starting date as soon as possible.
The research fellow must take part in the University’s/ Faculty’s/ Department’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.
The applicant must, in collaboration with her/his supervisor, within 3 months after employment, have worked out a complete project description to be attached to the application for admission to the doctoral program. For more information, please see our web site: Application and admission - PhD
More about the position
The project titled “Macro domain proteins and Mono-ADP-ribosylation modulate breast carcinogenesis” addresses the role of mono-ADP-ribosylation and the enzymes that regulate this post-translational modification in breast cancer growth. The emphasis of the project will investgiate the specific roles of the proteins, macrodomain 1 and poly-ADP-ribose polymerase 7 (PARP7), in estrogen-dependent and triple negative breast cancer cells. PARP7 is a mono-ADP-ribosyltransferase that adds ADP-ribose to itself and target proteins, while macrodomain 1 is a ADP-ribosylase that binds to and removes this post translational modification. Preliminary data suggest that PARP7, mono-ADP-ribosylation and macrodomain 1 are important regulators of breast carcinogenesis and may represent novel therapeutic targets for the disease. The aim of the project is to study and characterize the PARP7-macrodomain 1 signalling axis at the molecular and cellular levels.
The candidate will use cell culture, gene expression, gene knockdown/knockout, next gen sequencing (ChIP-Seq, RNA-Seq) and mass spectrometry and proteomic approaches throughout this project. The successful candidate will organize and execute the study, as well as analyze and publish the data. The candidate should therefore have a good background in biochemistry and molecular biology or related fields.
Qualification requirements
The Faculty of Medicine has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.
- The applicant must document the following qualifications: either a medical degree (M.D. or equivalent such as cand. med.) or a master’s degree (120 ECTS; minimum grade B ECTS grading scale) or equivalent. The master’s degree must include a thesis of at least 30 ECTS and be in a subject relevant to the positions, such as biology, medicine, molecular biology, pharmacology & toxicology, chemistry or biochemistry.
- The average grade point for courses included in the Bachelor’s degree must be C or better in the Norwegian educational system.
- Ability to work independently as well as in a team
- Proficiency in spoken and written English
We are seeking a highly motivated, enthusiastic person with good interpersonal skills, who also has the ambition of publishing papers in leading international journals.
We offer
- Salary NOK 442 400 – 497 000 per annum depending on qualifications and seniority as PhD Research fellow
- A dynamic, stimulating and collegial working environment
- Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities
How to apply
The application must include
- Application letter including a personal statement explaining the desire to pursue a PhD
- CV thar summarizes education, positions and relevant work experience
- Optional: List of publications (please do NOT append the publications)
- Copies of educational certificates and transcript records
- List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)
The application with attachments must be delivered in our electronic recruiting system, please follow the link “Apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project. Applicants may be invited to an interview and practical tests.
Formal regulations
Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.
According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.
Contact information
- Professor Jason Matthews, Phone +47-22851102, Email jason.matthews@medisin.uio.no