UiT The Arctic University of Norway

The Faculty of Health Sciences at UiT The Arctic University of Norway represents a newly created entity gathering almost all possible health study programs. This facilitates an unique interdisciplinarity and innovation in health education and research. We work closely with the services in the North to solve tomorrow's challenges.

Read more about us at uit.no/helsefak

UiT, The Arctic University of Norway, Faculty of Health Sciences has a Researcher position available. The position is attached to the Department of Clinical Medicine, K.G. Jebsen - Thrombosis Research and Expertise Centre (TREC) and the project title is “Identification and functional characterisation of novel endothelial-enriched proteins.”

The position is a fixed term position for a period of 2 years.

Further information about the position and project is available by contacting:

• Associate Professor Dr. Lynn Butler, phone +46 70 722 36 22, e-mail: lynn.m.butler@uit.no

Application and submitted documents (see below), shall be sent electronically via the application form available on www.jobbnorge.no.

About K.G. Jebsen TRECK.G. Jebsen TREC is a research centre in translational medicine funded by the Kristian Gerhard Jebsen Foundation, UiT – the Arctic university of Norway, and the North Norwegian Health Authorities. Professor John-Bjarne Hansen is the head of K.G. Jebsen TREC. The Centre has 5.2 permanent scientific positions (professors), 2 technical positions, and 15-20 temporary scientific positions (PhD-students and postdoctors). In addition, K.G. Jebsen TREC has partners in Tromsø, Bodø, Oslo, Stockholm, Leiden (The Netherlands), and San Diego (USA).

The overall aim of K.G. Jebsen TREC is to identify novel inherited and environmental risk factors and extend the understanding of the pathogenesis in venous thromboembolism (VTE). TREC is organized into three research groups; TREC-Clinic, TREC-Lab and TREC-Epidemiology. This position will be allocated to the TREC-Lab group. The appointed Researcher must have her/his daily workplace at UiT, campus Tromsø.

About the project

Endothelial cells (EC) line the inside of all blood vessels and have an important role in inflammation, maintenance of vascular tone, haemostasis and thrombosis development. We recently defined the body-wide EC-enriched transcriptome (Butler et. al. Cell Systems, 2016 3:287-301), using a new method to analysis RNAseq data from over 100 samples from different organs. It is well known that EC in different vascular beds have different properties, due to specialised tissue type-specific functions. Here, we will expand our knowledge of these differences to generate a ‘roadmap’ of EC-enriched proteins throughout the human body, by using our analysis method to define EC-enriched profiles in individual organs. We will select previously unstudied candidates for lab-based experimental analysis, using various criteria, which may include links to disease, such as VTE, or other indications of potential critical function. We will investigate the properties and cellular function of candidates. Techniques will include genetic manipulations (knockdown and over expression) in in vitro ‘model vessel’ systems, and in vivo murine models to study how the genes influence key EC functions, such as angiogenesis, inflammation and haemostatic processes.

Qualification requirements

For appointment as a Researcher, the applicant requires a Norwegian doctoral degree in cell biology, molecular biology or biochemistry or a corresponding foreign doctoral degree recognised as equivalent to a Norwegian doctoral degree.

Essential requirements:

Research experience in the vascular biology/endothelial cell field, with expertise in:

• Cell culture
• Standard laboratory techniques such as ELISA, Western blotting, immunocytochemistry, qPCR, flow cytometry

Desirable experience:

• Blood coagulation assays
• Plasmid production and expression and purification of recombinant proteins
• Biochemistry techniques e.g. enzymatic activity, kinetic constants, gel-filtration chromatography
• Primary cell isolation and culture from human and/or murine tissue
• Image analysis (confocal and phase contrast)
• Experience of analytical/statistical tools such as R, SPSS or Matlab

The level of experience and relevance will be given weight.

The candidate will be involved in supervision of PhD students on similar projects and, in addition, is expected to develop a project proposal with a progress plan. It is required that the applicant will be able to complete the project during the period of appointment.

The candidate must speak and write English fluently.

The candidate must be able to work systematically, independently and have the ability to work in an interdisciplinary research team. Emphasis will also be placed on communicative and collaborative skills, as well as personal suitability.

Working conditions

The working hours shall be utilised for research, research-related activities and research administration.

The successful applicant must be willing to engage himself/herself in the ongoing development of his/her discipline and the university as a whole.

The remuneration for this position is in accordance with the State salary scale code 1109.

A compulsory contribution of 2 % to the Norwegian Public Service Pension Fund will be deducted.

Applications shall be sent electronically via www.jobbnorge.no and shall include:

• cover letter including a short description of interests and reasons for applying for the position
• CV containing a complete overview of education, experience, professional work, pedagogical qualifications and references
• diplomas and certificates
• documentation of proficiency in English

• list of works and description of these

1. the list of works shall contain the following information:
2. author(s), the work’s title
3. for articles: the journal’s name and volume, the first and last page of the article, year of publication
4. for publications: publisher, printer, year of publication, number of pages

• academic works:

1. The applicant may submit up to ten works that are central to his/her production. The applicant’s doctoral thesis is regarded in this context as one work.

• In addition, the applicant shall provide a description of his/her production stating which works he/she considers the most important and which shall therefore be the main emphasis of the assessment. A brief description of the other listed works shall also be included to demonstrate depth of production.

Applications will only be considered if all requested application documents are received before the application deadline.

All documentation to be assessed must be translated into English.

Applications sent to us via e-mail or by any other means will not be considered.

Assessment

The applicants will be assessed by an expert committee. The committee’s mandate is to undertake an assessment of the applicants’ qualifications based on the application documents and the text of the announcement.

In the assessment, consideration may also be given to professional experience and any other activity which may be significant.

The applicants who are assessed as best qualified will be called to an interview. The interview shall, among other things, aim to clarify the applicant’s personal suitability for the position and motivations. A trial lecture may also be held.

General

In addition, applicants shall also refer to the supplementary provisions for the appointment to academic positions such as Postdoctoral Research Fellow, Research Fellow and Academic Assistant at UiT, The Arctic University of Norway, and to regulations concerning terms and conditions of employment for the posts Postdoctoral Research Fellow, Research Fellow, Research Assistant and Resident, which are available on the website “The Research Fellow file”.

Questions concerning the organisation of the working environment, including that of the physical state of the workplace, health services, possibilities for flexible working hours, part-time work, etc. may be addressed to the telephone reference in this announcement.

At UiT, The Arctic University of Norway, diversity is valued, and we therefore encourage all qualified applicants to apply regardless of their age, gender, functional ability or national or ethnic background. The university is an IW employer and places importance on making the necessary adaptations to working conditions for employees with disabilities.

Personal information given in an application and CV will be treated in accordance with the Act relating to the processing of personal data (the Personal Data Act). In accordance with section 25, subsection 2 of the Freedom of Information Act, the applicant may request not to be registered on the public list of applicants. However, the university may nevertheless decide to make the candidate’s name public. The applicant will receive advance notification of any such publication.

You can find more information on the website for arriving staff.

We look forward to receiving your application.

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