Job description

A 3-year position as a researcher (SKO 1109) is available at The Institute of Clinical Medicine, Division of Laboratory Medicine, Department of Pathology.

The candidate will be participating in the study of tumor-associated macrophages in colorectal cancer in Professor Frode Jahnsen’s laboratory, at the University of Oslo. The project will be performed in close collaboration with the laboratory of prof. Henk Stunnenberg, Radboud University, Nijmegen.

More about the position

The Jahnsen group studies complex interactions between immune cells in the human gut in various disease settings and their relationship with the gut microbiota. The Stunnenberg group focuses on the molecular basis of development and differentiation emanating from the genome and epigenome in the context of health and disease with emphasis on cancer.

The Jahnsen and Stunnenberg groups have recently performed a detailed characterization of the macrophage population in the intestine (Bujko, Atlasy et al, J Exp Med, 2017). By directly building on this information, this project aims to apply state-of-the-art molecular technologies to identify molecules and molecular pathways expressed by tumor-associated macrophages that can be targeted to strengthen anti-tumoral immunity in colorectal cancer.

The study will include molecular profiling of immune cells isolated within and outside colorectal cancers using RNA-seq, single cell RNA-seq and epigenetic studies. The study also includes flow cytometry/CyTOF. The clinical material will be processed in the Jahnsen lab, but the candidate will spend extended periods in the Stunnenberg laboratory analyzing the data.

For more information about the research groups:

http://www.med.uio.no/klinmed/english/research/groups/mucosal-immunity-in-gut/index.html

http://molbio.science.ru.nl/about/molecular-biology/henk-stunnenberg

Qualification requirements

• Interested candidates must have obtained a Ph.D. with background in computational biology, molecular biology, immunology, cell biology, or a related discipline.
• Experience in cancer biology and inflammatory diseases are highly desirable but not required.
• In general, quality of past research is more important than experience in a specific field.
• Preferably strong background in computational biology.
• Prior experience in molecular biology and immunology is desirable.
• Fluent oral and written communication skills in English.

Personal skills

• We are looking for a talented and highly motivated researcher
• The candidate should be highly motivated and dedicated, proficient in written and spoken English
• Good team working skills are required

We offer

• Salary NOK 524 200 – NOK 597 400 per annum depending on qualifications in position as Researcher (position code 1109).
• A professionally stimulating working environment
• Attractive welfare benefits
• Generous pension agreement

How to apply

The application must include

• Cover letter (statement of motivation, summarizing scientific work and research interest)
• CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
• Copies of educational certificates (academic transcripts only)
• A complete list of publications
• List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)

The application with attachments must be delivered in our electronic recruiting system Jobbnorge. Foreign applicants are advised to attach an explanation of their University’s grading system. Please note that all documents should be in English (or a Scandinavian language).

In assessing the applications, special emphasis will be placed on the documented, academic qualifications, the project description (whenever this is required in the call for applicants), and the quality of the project as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.It is expected that the successful candidate will be able to complete the project in the course of the period of employment.

Formal regulations

Please see the guidelines and regulations for appointments to researcher positions at the University of Oslo.

According to the Norwegian Freedom and Information Act (Offentleglova), information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.

Contact information

• Professor F. Jahnsen, e-mail: f.l.jahnsen@medisin.uio.no
• HR adviser Karoline Berg-Eriksen (questions regarding the online application form), e-mail: Karoline.berg-eriksen@medisin.uio.no

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